Melissa BrimerGranular Corneal Dystrophy
Melissa Brimer
CASE REPORT
What is Granular Corneal Dystrophy
Granular corneal dystrophy is a rare, inherited, autosomal dominant disease caused by a mutation on
the BIGH3 gene on chromosome 5q31. The disease is bilateral and often affects both eyes similarly, but it may
be asymmetric also. It is characterized by small granules or particles developing in the stromal layer of the
cornea. The disease usually presents in the first decade of life, with the granules becoming increasingly larger
and more numerous with age.